阿托伐他汀与辛伐他汀治疗高脂血症的疗效比较

目的比较阿托伐他汀与辛伐他汀治疗高脂血症的疗效。方法将98例患者随机分为阿托伐他汀组(52例)和辛伐他汀组(46例),阿托伐他汀剂量为10mg/d,辛伐他汀剂量为20mg/d,均口服治疗,疗程为8周。结果治疗8周后,两组的总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)均显著下降,降低幅度差异有统计学意义(P<0.05)。高密度脂蛋白胆固醇(HDL-C)无明显升高(P>0.05)。结论阿托伐他汀和辛伐他汀均为高效、安全的降脂药物。

Objective To evaluate the efficacy of atorvastatin and simvastatin in treatment of hyperlipimia.Methods 98 cases with compound hyperlipimia were randomly divided into two groups for 8 weeks.One is group A with atorvastatin 10mg/d and the another is group B with simvastatin 20mg/d.Results During therapy for 8 weeks,the levels of TC,TG and LDL-C significantly decreased for two groups before and after therapy.The different was more significant between two groups（P0.05）.Both of them could not elevate the levels of HDL-C after 8 weeks treatment（P0.05）.Conclusion Astovastatin and simvastatin are both safe and effect medicine in treatment of patient with compound hyperlipimia.