环孢素A联合激素冲击治疗原发性肾病综合征的临床研究

目的探讨环孢素A联合激素冲击治疗原发性肾病综合征的临床疗效,提高临床治疗效果。方法 80例原发性肾病综合征患者采用随机数字表的方法,分为观察组和对照组各40例,两组患者均给予常规治疗,对照组加用激素冲击治疗,观察组加用环孢素A联合激素冲击治疗;随访1年,比较两组患者的临床治疗效果。结果观察组总有效率70.00%,明显高于对照组的45.00%,差异有统计学意义(P<0.05)。结论环孢素A联合激素冲击治疗原发性肾病综合征,临床有效率高,可有减少24h尿蛋白,值得临床推广应用。

Objective To explore the clinical efficacy of cyclosporin A combined with steroid pulse therapy in patients with primary nephrotic syndrome.Methods 80 cases patients with primary nephrotic syndrome were divided randomly into the intervention group（40 cases） and the control group（40 cases）;the patients in intervention group were treated with cyclosporin A combined with steroid pulse therapy,the control group was treated with steroid pulse therapy,in a one-year follow,the clinical efficacy was observed and compared.Results The total effective rate in intervention group was 70.00%,higher than 45.00% in control group,have a statistically significant difference（P0.05）.Conclusion Cyclosporin A combined with steroid pulse therapy in patients with primary nephrotic syndrome is obviously effective and safe,has high relieving rate,and hence is worthy of being recommended in clinical practice.