水朝阳旋覆花化学成分研究

Chemical Constituents from Inula helianthus-aquatica

目的:研究水朝阳旋覆花Inula helianthus-aquatica的化学成分。方法:运用正/反相硅胶柱色谱、Sephadex HL-20凝胶色谱、HPLC等色谱学方法分离纯化化合物,MS,NMR等波谱学方法鉴定化合物结构。结果:从水朝阳旋覆花中分离鉴定出11个化合物,其中7个倍半萜內酯:11α,13-dihydrotomentosin(1),sundiversifolide(2),8-epi-xanthatin-1β,5β-epoxide(3),ivaxillin(4),11,13-dehydroivaxillin(5),1β-hydroxyalantolactone(6),carabrone(7);4个三萜类化合物:taraxasterol 3-O-acetate(8),maniladiol 3-O-palmitate(9),16β-hydroxylupeol 3-O-tetradecanoate(10),arnidiol(11)。结论:所有化合物均为首次从该植物中分离得到。

Objective：To investigate the chemical constituents of Inula helianthus-aquatica.Eleven compounds were isolated from the title plant.Method： These compounds were isolated by various chromatography methods such as silica gel,RP-18 silica gel,Sephadex LH-20 gel,HPLC,et al.Their structures were elucidated by spectral analysis like MS,NMR.Result： Seven sesquiterpene lactones were isolated and elucidated as 11α,13-dihydrotomentosin（1）,sundiversifolide（2）,8-epi-xanthatin-1β,5β-epoxide（3）,ivaxillin（4）,11,13-dehydroivaxillin（5）,1β-hydroxyalantolactone（6）,carabrone（7）.Four triterpenes were isolated and elucidated as taraxasterol 3-O-acetate（8）,maniladiol 3-O-palmitate（9）,16β-hydroxylupeol 3-O-tetradecanoate（10）,arnidiol（11）.Conclusion： All the compounds were isolated from I.helianthus-aquatica for the first time.