强心宁煎剂对慢性心力衰竭心肾阳(气)虚、血瘀水停证患者血浆TNF-α,IL-6的影响

Effect of Qiangxinning Jianji on Plasma Levels of TNF-α,IL-6 in Chronic Heart Failure Patients

目的:探讨强心宁煎剂对慢性心力衰竭(CHF)患者血浆肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的影响。方法:将68例CHF患者随机分为治疗组和对照组(每组34例),治疗组在对照组常规西药治疗基础上加用强心宁煎剂。2组于治疗前后分别测定血浆TNF-α,IL-6水平,同时评估NYHA心功能分级。结果:治疗后2组NYHA心功能分级均较同组治疗前改善(P<0.05),且治疗组优于对照组(P<0.05);同时治疗组血浆TNF-α,IL-6水平明显下降,与对照组及同组治疗前比较差异显著(P<0.05)。结论:强心宁煎剂能够降低CHF患者血浆TNF-α,IL-6水平,可作为治疗CHF有效药物之一。

Objective：To investigate the effect of Qiangxinning Jianji on plasma levels of tumornecrosis factor alpha（TNF-α）,interleukin-6（IL-6） in chronic heart failure（CHF） patients.Method：CHF patients were randomly divided into the treatment group and control group.Plasma levels of TNF-α and IL-6 were measured and NYHA class was evaluated at the 8th week of treatment.Result：NYHA class was markedly improved in two groups,it was significantly better in treatment group than those in the control group（P0.05）.As compared with the control group,in the treatment group;TNF-α and IL-6 were lower,the difference between groups and between before and after treatment were significant（P0.05）.Conclusion：Qiangxinning Jianji could lower plasma levels of TNF-α and IL-6,and is one of the effective drugs in improving cardiac function in patients with CHF.