摘要
目的:探讨强心宁煎剂对慢性心力衰竭(CHF)患者血浆肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的影响。方法:将68例CHF患者随机分为治疗组和对照组(每组34例),治疗组在对照组常规西药治疗基础上加用强心宁煎剂。2组于治疗前后分别测定血浆TNF-α,IL-6水平,同时评估NYHA心功能分级。结果:治疗后2组NYHA心功能分级均较同组治疗前改善(P<0.05),且治疗组优于对照组(P<0.05);同时治疗组血浆TNF-α,IL-6水平明显下降,与对照组及同组治疗前比较差异显著(P<0.05)。结论:强心宁煎剂能够降低CHF患者血浆TNF-α,IL-6水平,可作为治疗CHF有效药物之一。
Objective:To investigate the effect of Qiangxinning Jianji on plasma levels of tumornecrosis factor alpha(TNF-α),interleukin-6(IL-6) in chronic heart failure(CHF) patients.Method:CHF patients were randomly divided into the treatment group and control group.Plasma levels of TNF-α and IL-6 were measured and NYHA class was evaluated at the 8th week of treatment.Result:NYHA class was markedly improved in two groups,it was significantly better in treatment group than those in the control group(P0.05).As compared with the control group,in the treatment group;TNF-α and IL-6 were lower,the difference between groups and between before and after treatment were significant(P0.05).Conclusion:Qiangxinning Jianji could lower plasma levels of TNF-α and IL-6,and is one of the effective drugs in improving cardiac function in patients with CHF.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第14期264-266,共3页
Chinese Journal of Experimental Traditional Medical Formulae