中药代谢动力学研究概述

Overview about Pharmacokinetics of Traditional Chinese Medicine Study

介绍近年来中药代谢动力学的研究方法及其检测分析方法。查阅了国内外有关的30多篇文献,进行归纳整理并分类汇总。文献报道中药代谢动力学的研究方法以血药浓度法为主,还有证治药动学,中药血清药理学,中药胃肠动力学,PK-PD模型等新方法。检测分析方法以液相法为主,而色谱联用技术的应用更为中药代谢动力学研究开创了新的思路。我国中药代谢动力学的研究已初具规模,对单味中药的单体成分的代谢研究较多,今后的研究应对中药复方的代谢过程及作用机制进行探索,以寻求更好的复方代谢研究途径。

To review the research methods of pharmacokinetics of traditional Chinese medicine（TCM） and detect analysis methods in recent years.Papers reported in journals were consulted and classified,according to the domestic and overseas literatures over 30 papers.The blood medicine density is the main study method of pharmacokinetics of TCM,still including syndrome and treatment pharmacokinetics,serum pharmacology of TCM,gastrointestinal dynamics of TCM,modeling of pharmacokinetic-pharmacodynamic（PK-PD） and so on.The Liquid Chromatography（LC） is the substantial methods of detect analysis and hyphenated techniques chromatography（HTC） has founded new thoughts to studying the pharmacokinetics of TCM.The pharmacokinetics of TCM has already begun to take scale,but it is concentrate on study of single compounds of TCM.Future researches should focus on explore the metabolism process and function mechanism of traditional chinese prescription to seek better research approaches.