摘要
帕金森病以黑质多巴胺能神经元变性、缺失和路易小体形成为病理特征，其发生机制与黑质纹状体系统氧化应激反应增强、自由基增多损害多巴胺能神经元等密切相关。研究发现尿酸、8-羟基脱氧鸟苷、谷胱甘肽、铁和白介素-6等血生物学指标在帕金森病患者发生了有意义的变化，本文就此作一综述。
Parkinson＇ s disease （PD） is a common neurodegenerative disorder, characterized by progressive degeneration of the dopaminergic neurons in the substantia nigra pars compacta （SNpc） and generation of Lewy body. The exact mechanisms remain unknown. However oxidative stress and free radical are generally thought to play a prominent role in the etiology of PD. Several studies suggest that uric acid, 8 - hydroxy - 2＇- deoxyguanosine, glutathione, iron, interleukin - 6 and other biomarkers of blood in PD patients have been significantly changed.
出处
《国际老年医学杂志》
2011年第4期161-165,共5页
International Journal of Geriatrics
基金
江苏省自然科学基金项目（BK2010229）江苏省高校自然研究计划项目（08KJB320012）苏州市科技发展计划（社会发展及医药）资助项目（200815404）
