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血管生成素-2对缺血性脑血管病脑微血管生成作用机制的研究进展 被引量:2

Research Progress in Angiopoietin- 2 on Mechanism of Cerebral Angiogenesis in Ischemic Cerebrovascular Disease
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摘要 血管生成素-2在脑缺血半暗带血管新生和侧支循环的形成过程中发挥重要作用。本文将从血管生成素-2的结构,在血管生成中的生物学特性,以及在脑缺血后微血管生成中的利弊影响等方面对其作一综述,同时对其应用于治疗性血管生成过程中遇到的问题及应用前景予以分析。 Angiopoietin -2 plays an important role in angiogenesis and collateral circulation in cerebral ischemic penumbra. This paper reviews the structure of Ang - 2, the biological characteristics in angiogenesis and balance effects of angiogenesis in post injury of cerebral ischemia. The problems and the future prospects of Ang -2 in therapeutic angiogenesis are also discussed in this article.
出处 《国际老年医学杂志》 2011年第4期171-175,共5页 International Journal of Geriatrics
基金 国家自然科学基金资助项目(30772842)河南省杰出青年基金项目(0612000700)
关键词 血管生成素-2 缺血性脑血管病 血管生成 Angiopoietin - 2 Cerebral isehemia Angiogenesis
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  • 1Beck H, Plate KH. Angiogenesis after cerebral ische- mia [J]. Acta Neuropathol, 2009, 117 (5): 481- 496.
  • 2Brea D, Sobrino T, Ramos - Cabrer P, et al. Reor- ganisation of cerebral vasculature following ischemia [J]. Rev Neurol, 2009, 48 (12): 645-654.
  • 3Navaratna D, Guo Shuzhen, Arai K, et al. Mecha- nisms and targets for angiogenic therapy after stroke [J]. Cell Adhesion Migration, 2009, 3 (2) : 216 - 223.
  • 4Chaparro M, Sanz- Cameno P, Trapero M, et al. Mechanisms of angiogenesis in chronic inflammatory liv- er disease [J]. Ann H epatol, 2007, 6 (4): 208- 213.
  • 5Das SK, Vasudevan DM. Essential factors associated with hepatic angiogenesis [J]. Life Sci, 2007, 81 (23/24) : 1555 - 1564.
  • 6Shim WS, Ho IA, Wong PE. Angiopoietin: a Tie (d) balance in tumor angiogenesis [ J ]. Mol Cancer Res, 2007, 5:655 -665.
  • 7Bach F, Uddin FJ, Burke D. Angiopoietins in malig- nancy [J]. Eur J Surg Oncol, 2007, 33:7 -15.
  • 8Phelps ED, Updike DL, Bullen EC, et al. Transcrip- tional and posttranseriptional regulation of angiopoietin -2 expression mediated by IGF and PDGF in vascular smooth muscle cells [J]. Am J Physiol Cell Physiol, 2006, 290:C352 - C361.
  • 9Takahashi Y, Nishikawa M, Takakura Y. Inhibition of tumoreell growth in the liver by RNA interference media- ted suppression of HIF - 1 alpha expression in turn or cells and hepatocytes [ J ]. Gene Ther, 2008, 15 (8): 572-582.
  • 10Maisonpierre PC, Suri C, Jones PF, et al. Angiopoi- etin- 2, a natural antagonist for tie -2 that distruptin vivo Angiogenesis [ J ]. Science, 1997, 277 (5322): 55-66.

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