1Tree J A,Richardson C,Fooks A R.. Comparison of largescale mammalian cell culture systems with egg culture for the production of influenza virus A vaccine strains [J]. Vaccine, 2001,19:3444-3450.
2Govorkova E A,Kodihalli S,Alymova I V,et al. Growth and immunogenicity of influenza viruses cultivated in Veto or MDCK cells and in embryo-nated chicken eggs [J]. Dev Biol Stand, 1999,98 : 39-51,73-34.
3Pau M G. The human cell line PER.C6 provides a new manufacturing system for the production of influenza vaccines[J]. Vaccine,2001,19:2716-2721.
4Folkman J,Moscona A. P,.ole of cell shape in growth control[J]. Nature, 1978,273 : 345-349.
5Chu C,Lugovtsev V,Golding H,et al. Conversion of MDCK cell line to suspension culture by transfecting with human siatTe gene and its application for influenza virus production [J]. Proc Nail Acad Sci USA,2009,106(35) : 14802-14807.
6Tree J A,Richardson C,Fooks A R,et al. Comparison of large-scale mammalian cell culture systems with egg culture for the production of influenza virus A vaccine strains [J]. Vaccine, 2001,19:3444-3450.
7Tsuchida A. Synthesis of disialyl Lewis a (Le(a))structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides [J]. Biol Chem, 2003,278 : 22787-22794.
8Marton L J. Antizyme induetion by Polyamine analogues as a factor of cell growth inhibition [J]. The Bioehemieal Journal, 2002,366 (2) : 663-671.
9Lohr V,P,.ath A,Geuzel Y. New avian suspension cell lines provide production of influenza virus and MVA in serum-free media:studies on growth,metabolism and virus propagation [J]. Vaccine, 2009,27 : 4975-4982.
10Van Wiehnk R. Adaptation of a Madin-Darby canine kidney cell line to suspension growth inserum-free media and comparison of its ability to produce avian influenza virus to Vero and BHK21 cell lines [J ]. Virol Methods, 2010,8 : 11354-11355.
5SAIF Y W.禽病学[M].高福,苏敬良,索勋译.12版.北京:中国农业出版社,2012:210-239.
6PIZZI M. Sampling variation of the fifty percent endpoint, determined by the Reed-Muench (Behrens) method [J]. Hum Biol, 1950,22(3): 151-190.
7HIMLY M, FOSTER D N, BOTTOLI I, et al. The DF-1 chicken fibro-blast cell line:Transformation induced by di- verse oncogenes and cell death resulting from infection by avian leukosis viruses[J]. Virology,1998,248(2):295-304.
8BRUCKHOFF B. The production of influenza vaccines from MDCK cell cultures[J]. Pharmazie in unserer Zeit, 2012,40(2) : 140-142.