阻塞性睡眠呼吸暂停综合征与认知功能损害

Obstructive sleep apnea syndrome and cognitive function impairment

阻塞性睡眠呼吸暂停综合征(OSAS)患者认知功能的损害普遍存在,不同程度的影响了患者的生存质量。这个常见的OSAS合并症却经常被漏诊,使患者得不到及时的诊断和治疗。认知功能损害的机制主要与睡眠间歇低氧和睡眠结构紊乱有关,间歇低氧引发的炎症和氧化应激反应对认知功能相关部位的中枢神经损伤是认知功能障碍的解剖学基础。充分治疗OSAS对认知功能的改善有益,提倡对患者的早期诊断和治疗。

Summary： Cognitive function impaired was very common in patients with OSAS, it impacted the quality of life in patients with OSAS. But the common problem with OSAS was usually missed diagnosis. The patients could not be diagnosed and treated early. The mechanism of cognitive function impaired related to sleep intermittent hy- poxia and sleep fragmentation. The inflammatory and oxidative stress reaction caused by intermittent hypoxia could injury the parts of central nerve system that related to cognitive function. The cognitive function impaired was improved after treatment of OSAS. It is necessary to early diagnose and treat cognitive function impaired with OSAS patients.