普通维生素D与骨质疏松

Application of plain vitamin D in prevention and treatment of osteoporosis

维生素D缺乏所致的儿童佝偻病和成年后骨软化会促发并加重年老后发生的骨量减少或骨质疏松。因此，充足的维生素D是保证有效预防和治疗骨质疏松的基础。反映体内维生素D水平的最佳指标是血清25-羟维生素D[25（OH）D]，其水平与骨密度、骨折风险和跌倒风险呈负相关。最优化的25（OH）D范围为30～50μg／L，20～〈30μg/L为不足，低于20μg/L为缺乏。推荐老年人每天补充800～1000U普通维生素D，骨质疏松患者、肥胖、缺乏日照和吸收不良的人可酌情增加至2000U。

Summary：Rickets in children and osteomalacia in adults resulting from vitamin D deficiency will precipitate and exacerbate osteopenia and osteoporosis after aging. Therefore vitamin D supplement is one of the fundamental interventions to prevent and treat osteoporosis. The best index to determine an individual＇s vitamin D status is the serum 25-Hydroxyvitamin D[ 25 （ OH ） D ] which negatively predicts bone mineral density, and risks of fractures and falls. The optimal range of 25 （OH）D concentration is 30 ~ 50 txg/L,while 20 ~ 〈 30 txg/L is regarded as insuffi- ciency,and less than 20 p,g/L-deficiency. The recommended dosage is 800 ~ i000 U/d of plain vitamin D for healthy old people and up to 2000 U/d for people with osteoporosis, obesity, poor sun exposure, and malabsorption.