摘要
成纤维细胞是瘢痕形成的效应细胞,瘢痕疙瘩和肥厚性瘢痕成纤维细胞存在着广泛的异质性。成纤维细胞胶原合成增加、降解减少导致病理性瘢痕中胶原过度积聚。成纤维细胞的增殖异常是病理性瘢痕过度增生和持续存在的主要原因。成纤维细胞对细胞因子等因素反应性有明显异常。肥厚性瘢痕的收缩性和成纤维细胞的异质性有直接关系。
出处
《国外医学（皮肤性病学分册）》
1999年第6期336-339,共4页
Foreign Medical Sciences(Section of Dermatology and Venereology)
参考文献1
-
1Aziz Ghahary,You J. Shen,Bernadette Nedelec,Paul G. Scott,Edward E. Tredget. Enhanced expression of mRNA for insulin-like growth factor-1 in post-burn hypertrophic scar tissue and its fibrogenic role by dermal fibroblasts[J] 1995,Molecular and Cellular Biochemistry(1):25～32
同被引文献13
-
1马列,高长有,沈家骢.皮肤组织工程和再生医学材料的研究进展[J].组织工程与重建外科杂志,2007,3(3):121-125. 被引量：4
-
2Kundu BI, Rajkhowa R, Kundu SC, Wang X. Silk fibroinbiomaterials for tissue regenerations[J]. Adv Drug Deliv Rev,2013, 65(4):457-470.
-
3Chitturi RT, Balasubramaniam AM, Parameswar RA. The roleof myofibroblasts in wound healing, contraction and its clinicalimplications in cleft palate repair[J]. J Int Oral Health, 2015,7(3):75-80.
-
4Torr EE, Ngam CR, Bernau K. Myofibroblasts exhibit enhancedfibronectin assembly that is intrinsic to their contractilephenotype[J]. J Biol Chem, 2015, 290(11):6951-6961.
-
5Darby IA, Hewitson TD. Fibroblast differentiation in woundhealing and fibrosis[J]. Int Rev Cytol, 2007, 257:143-179.
-
6Desmoulière A, Redard M, Darby I, Gabbiani G. Apoptosismediates the decrease in cellularity during the transition betweengranulation tissue and scar[J]. Am J Pathol, 1995, 146(1):56-66.
-
7Sanders YY, Cui Z, Le Saux CJ, SMAD-independent downregulationof caveolin-1 by TGF-β: effects on proliferation andsurvival of myofibroblasts[J]. PLoS One, 2015, 10(2):e0116995.
-
8Zhang HY, Phan SH. Inhibition of myofibroblast apoptosis bytransforming growth factor beta(1)[J]. Am J Respir Cell MolBiol, 1999, 21(6):658-665.
-
9Aoki M, Miyake K, Ogawa R. siRNA knockdown of tissueinhibitor of metalloproteinase -1 in keloid fibroblasts leadsto degradation of collagen type I[J]. J Invest Dermatol, 2014,134(3):818-826.
-
10Farhat YM, Al-Maliki AA, Easa A. TGF-β1 suppressesplasmin and MMP Activity in Flexor Tendon cells via PAI-1:implications for scarless flexor tendon repair[J]. J Cell Physiol,2015, 230(2):318-326.
二级引证文献2
-
1肖阳,杨琼,李庆荣,邢东旭,罗国庆,叶明强.丝素蛋白在生物医药工程中的应用[J].广东蚕业,2016,50(2):24-29. 被引量：5
-
2吴晴晴,肖贵喜,贾立平,陆静,胡亮,陆晓蔚,吕庆兵,包亚明.脱细胞猪小肠黏膜下层与猪脱细胞真皮基质作为真皮支架的对比研究[J].中国美容医学,2022,31(7):114-118.
-
1叶小莉,魏平.综合疗法治疗瘢痕疙瘩、肥厚性瘢痕120例临床疗效观察[J].中国煤炭工业医学杂志,2003,6(7):606-606. 被引量：1
-
2王韦,马永江.防止胶原在体内降解及其临床应用[J].国外医学（创伤与外科基本问题分册）,1990,11(2):87-91.
-
3石佳.瘢痕形成中细胞因子的作用[J].中华医学写作杂志,2003,10(1):77-79.
-
4阿地里．吾提库,沈俊峰.74例腹股沟疝无张力修补术临床分析[J].健康必读（下）,2011(3):62-62.
-
5潘东亚.74例腹股沟疝无张力修补术临床分析[J].中国中医药咨讯,2011,3(13):77-77.
-
6曹圣光.74例腹股沟疝无张力修补术临床分析[J].大众健康（理论版）,2012(11):143-144.
-
7李高峰,罗成群.低氧对瘢痕形成的影响[J].中华整形外科杂志,2003,19(5):383-386. 被引量：6
-
8张玲,武继祥,张雪,李世荣.肥厚性瘢痕和瘢痕疙瘩的多种治疗方案进展[J].中国临床康复,2005,9(30):135-135.
-
9李书忠,陈培勋,胡有谷.正常椎间盘胶原的研究[J].生物化学杂志,1993,9(2):184-189. 被引量：5
-
10洪斯同.胶原与胶原酶[J].中国烧伤创疡杂志,2000,12(2):64-65. 被引量：3
