铀在小鼠体内的分布及其影响因素的初步探讨

THE BIODISTRIBUTION OF URANIUM IN MICE

通过尾静脉注射给药方式研究UO22+在小鼠体内的分布,通过建立包含主要体液的金属离子、小分子配体及UO22+及其配合物的热力学函数的热力学平衡模型,采用数值模拟方法研究UO22+在体液中的形态.研究表明,给药后铀的重要沉积部位为骨骼、肾脏和肝脾脏,主要通过小鼠肾脏排泄.肝脾脏器中铀的浓度随时间变化有两个峰值.血液中铀的清除速度较快.计算机模拟表明,血浆内UO22+主要以带电荷的UO22+配位离子形式存在,血浆内UO22+形态与总铀浓度相关.UO22+能与PO34-等离子形成溶度积很高的固态物质,造成UO22+长期沉积在骨骼,尿液中出现固相(UO2)3(PO4).24H2O固相物质.

This article studies UO2＋2 distribution in mice through the tail intravenous injection.Through the establishment of a thermodynamic equilibrium model,using a function of metal-ions,low molecular weight molecule ligands and complexes of UO2＋2,the speciation of UO2＋2in body fluids was simulated numerically.The results show that,after administration,the major uranium deposition sites are bones,kidney,liver and spleen.UO2 was eliminated mainly through renal excretion,and its concentration in the liver and spleen peaked twice over time.The removal of uranium in the blood fast.Computer simulation showed that the major UO2＋2 species at normal blood plasma pH value were UO2＋2 complex ions.The species of UO2＋2 in the plasma blood is dependent on the total uranium concentration.UO2＋2 forms high-solubility solids with PO3-4 and other ions,resulting in UO2＋2 long-term deposition in the bone.Computer simulation also shows（UO2）3（PO4）2·4H2O solid also forms in the urine.