黏着斑蛋白vinculin在子宫内膜异位症组织中表达的初步研究

Preliminary study of vinculin expression in endometriosis

目的初步探讨黏着斑蛋白(vinculin)在正常子宫内膜、子宫内膜异位症(EMs)患者在位内膜、异位内膜间的表达差异。方法用免疫组化法和Western blot分析,研究3例增生中晚期正常子宫内膜、3例增生中晚期EMs患者的在位内膜和异位内膜中vinculin的表达差异。结果 vinculin主要表达于细胞外质和细胞质中,且EMs患者异位内膜中的表达强度高于在位内膜与正常内膜中的表达(P<0.05);而患者在位内膜和正常内膜中的表达差异无统计学意义(P>0.05)。结论 vincu-lin可能参与EMs的发生和发展。

Objective To study the different expressions of vinculin among normal endometrial,eutopic and ectopic endometria of patients with endometriosis.Methods The expression differences among three normal proliferate-stage endometria,three proliferate-stage eutopic and ectopic medometria of patients with endometriosis were examined by immunohistochemistry and Western blot.Results Vinculin was located in both the ectoplasm and cytoplasm.The expression level of vinculin in ectopic endometrial of patients with endometriosis was stronger than those in eutopic endometria of patients with endometriosis and normal endometrial（P0.05）,while the difference between eutopic endometria of patients with endometriosis and normal endometria was not significant（P0.05）.Conclusion Vinculin may play an important role in the pathogenesis of endometriosis.