替吉奥治疗老年进展期胃癌临床观察

Clinical investigation of S-1 alone in the treatment of elderly patients with advanced gastric cancer

目的观察替吉奥胶囊单药治疗老年进展期胃癌的临床疗效及不良反应。方法 33例老年进展期胃癌患者,应用替吉奥胶囊口服,至少完成2个周期后评价疗效和不良反应。结果 33例患者中完全缓解(CR)1例(3%)、部分缓解(PR)12例(36.4%)、稳定(SD)6例(18.2%),总有效率RR39.4%,生活质量改善12例(36.4%),主要毒副反应为血液学毒性和消化道反应。结论替吉奥胶囊是治疗进展期胃癌安全、有效的药物,特别适宜于老年体弱的患者。

Objective To evaluate the efficacy and toxicity of S-1 alone in the treatment of elderly patients with advanced gastric cancer.Methods Thirty-three elderly patients with advanced gastric cancer were treated with S-1 capsule.The evaluation of efficacy and toxicity were performed on all patients after 2 cycles.Results Of the 33 patients,there was 1（3%） complete remission（CR）,12（36.4%） partial remission（PR）,6（18.2%） stable disease（SD）.The total response rate was 39.4%.KPS improvement rate was 36.4%,the major toxicities were myelo suppression and gastrointestinal reaction.Conclusion S-1 capsule is safe and effective in the treatment of advanced gastric cancer,especially for patients old and frail.