硝唑尼特对四翼无刺线虫的驱虫效果

Therapeutic Effect of Nitazoxanide on Aspiculuris tetraptera

20只自然感染四翼无刺线虫的雌性昆明系小鼠,随机分成4组,每组5只,常规饲喂。第1-3组小鼠分别以200、400、800 mg/kg剂量的硝唑尼特灌胃,第4组设为空白对照组,每24 h一次,连续灌胃5 d。用虫卵减少率和粗计驱虫率作为评价药物效果的指标。结果显示,硝唑尼特对四翼无刺线虫的驱虫效果随药物剂量的增加而提高,以800 mg/kg剂量效果最好。

Twenty mice infected with Aspiculuris tetraptera naturally were assigned randomly into four groups（n=5）.GroupsⅠ-Ⅲ were fed with Nitazoxanide at a dosage of 200,400,800 mg/kg every 24 hours for 5 consecutive days,group Ⅳ with no treatment were used as the control.Faecal egg count reduction percentage and crude insecticide rate were used as the evaluation of drug effects of insecticide targets.The results showed that the insecticide effect of Nitazoxanide on Aspiculuris tetraptera increased with the increase of drug dose,and the dose of 800 mg/kg had the best effect.