猪脾转移因子的制备及临床应用

Preparation and Therapeutically Application for Transfer Factor of Porcine Spleen

本试验采用透析法提取猪脾转移因子(TF),并对其理化性质、生物活性、安全性进行了研究。结果表明,TF可增强小鼠腹腔巨噬细胞的吞噬功能,体外抑菌结果显示金黄色葡萄球菌、大肠杆菌、沙门氏菌对转移因子敏感,而链球菌不敏感。对猪流行性腹泻、猪传染性胃肠炎分别使用TF(0.2、0.1、0.05 mL/kg)和药物进行治疗,结果表明使用0.1 mL/kg TF的剂量效果较好。

In this experiment,transfer factor was extracted by dialysis from porcine spleen and physics and chemistry nature,biological activity,safety testing was researched,the result showed that TF could enhance the phagocytosis of mouse peritoneal macrophages,TF was sensitive to Staphylococcus,E.coli,Salmonella,but had little effects on Streptococci.We used TF（0.2,0.1,0.05 mL/kg）respectively and drug treatment for porcine epidemic diarrhea and porcine circovirus,the result showed that 0.1 mL/kg use of the effect was better.