一剂复方中药对家兔骨骼愈合的影响

The Effects of One Chinese Herbal Medicine on Fracture Healing of Rabbits

复方中药对骨折愈合的作用机制目前尚不明确,本试验通过观察复方中药对家兔桡骨骨折后血清钙、磷、碱性磷酸酶和X线影像学等指标的影响,分析该中药促骨愈合的效能及其可能作用机理。试验选用48只成年家兔,制成骨缺损标准模型,随机分为试验组和空白对照组,试验组每日在饲料中添加复方中药2.5 g/kg饲喂,对照组给予普通饲料。分别于术后2、4、6、8周进行生化指标和X线影像学检测。试验结果表明,试验组血清钙、血清磷、血清碱性磷酸酶及X线片评分骨折后明显高于对照组。该复方中药能缩短骨折愈合过程所需时间,提高骨折愈合质量,有利于骨折愈合。

The pathways of Chinese herbal medicine in fracture healing are not very well understood.Therefore,the objective of the present study was to evaluate the effects of one compound Chinese herbal medicine on rabbits radius fracture healing using indexes（such as the serum Ca,P,serum ALP,and X-ray of bone fracture）.48 healthy mature rabbits were selected to build standard defect models,and randomly divided into experimental groups and control groups.The control rabbits were given standard diet.Experimental rabbits were fed with standard diet plus Chinese herbal medicine（2.5 g/kg） every day.The detection was performed on the 2,4,6 and 8 weeks after operation.The results of the study showed that the level of serum Ca,P,the activity of AKP and X-ray appearances for taking Chinese herbal medicine after fracture were significantly higher than that of the control.In conclusion,composite Chinese herbs might shorten the time to union,improve the quality of fracture healing and be beneficial to the fracture healing.