心肌肌钙蛋白I测定评价窒息新生儿心肌损害的临床价值

Determination CTnI to evaluate myocardial injury in asphyctic newborn

目的 探讨心肌肌钙蛋白Ｉ（ＣＴｎＩ）评估窒息新生儿心肌损害的临床价值。方法 放射免疫法测定窒息新生儿组３７ 例（ 轻度窒息１９ 例，重度窒息１８ 例）、对照组１０ 例，生后２４ 小时、３ 天、７ 天、１４ 天血清ＣＴｎＩ水平。结果 窒息组２４ 小时、３ 天、７ 天ＣＴｎＩ值明显高于对照组（ Ｐ＜０－０５），且ＣＴｎＩ水平与窒息严重程度呈正相关，窒息组治疗前后对比呈逐渐下降趋势。其中重度窒息组９ 例，Ｈｏｌｔｅｒ 示明显ＳＴ－ Ｔ 段改变者，其血清ＣＴｎＩ升高更明显。结论 ＣＴｎＩ的测定有助于早期预测心功能损害。

Objective\ To evaluate asphyctic neonatel myocardial injury,the variations of serum cardiac troponin(CTn I)levels in asphyctic newborn infants,we observed.Methods\ Dynamic variation of serum CTnI levels were measured at birth 1 day,3 days,7 days and 14 days,respectively,in 37 asphyctic newborn infants and 10 control neonates by radioimmunoassay.Results\ Serum CTnI of asphyctic neonates were significantly higher than that in the controls (P<0 05) and the levels of CTnI were positively correlated with the degree of asphyxia.9 cases Holter showed rapid ST-T wave change in severe asphyxia groups and the serum CTnI still high.The level of serum CTnI gradually decreased after therapy in asphyctic cases.Conclusions\ The elevation of serum CTnI was a highly specific marker of myocardial injury,and the determination of CTnI can help the prediction of the myocardial injury after asphyxia,therapy on time and to avoid heart failure,cardiac shock,myocardial necrosis,and so on.