医院2009年抗菌药物临床应用情况分析

Clinical application of antibiotics in 2009

目的分析总结医院2009年抗菌药物的临床应用情况。方法采用回顾性分析方法,分析2638份抗菌药物药品的出库资料和相关病历资料。结果共涉及8大类51个药品种类,以β-内酰胺类占58.3%、大环内酯类占14.0%、氨基糖苷类占12.7%为主;数量最多的前10位为头孢呋辛酯占13.3%、头孢哌酮/舒巴坦占11.8%、依替米星占8.8%、头孢唑肟占6.8%、左氧氟沙星占5.9%、克拉霉素占5.0%、阿莫西林占4.2%、头孢呋辛占3.2%、头孢西丁占2.8%和哌拉西林/他唑巴坦占2.5%;使用抗菌药物最多的3个科室为呼吸科占16.1%I、CU占14.9%和普外科占9.4%,临床用途主要是抗感染治疗占53.1%、预防感染占29.2%和预防+治疗占17.7%。结论加强抗菌药物的临床应用管理,对提高抗菌药物的合理应用具有重要意义。

OBJECTIVE To analyze and summarize the clinical application status of antibiotics in 2009. METHODS A retrospective analysis was used. The outbound data of 2638 cases given antibiotics were analyzed. RESULTS The drugs involved 8 sorts and. 51 species.β-lactam derivatives （58. 3%）, macrolide antibiotic （14. 0%） and aminoglycosides （12.7%） were the three main sorts of antibiotics. The largest number of top ten species were ceftazidime （13.3%）, cefoperazone/sulbactam （11.8%）, ceftriaxone （8.8%）, cefpiramide （6.8%）, cefotaxime （5. 9%）, meropenem （5. 0%）, leofloxacin （4. 2%）, clarithromycin （3. 2%）, vancomycin （2. 8%） and amoxicillin （2. 5%）. The three departments of respiratory, ICU and general surgery used antibiotics more frequently. The antibiotics were mainly used for anti-infection treatment （53.1%）, infection prevention （29.2 %） and combining prevention with control （17.7 %）. CONCLUSION It is important to strengthen the management of the clinical application of antibiotics to improve the reasonable use of antibiotics.