54种常用抗菌药物与转化糖注射液的配伍稳定性研究

A study of compatible stability between 54 antibiotics for injection and invert sugar infusion after mixing

目的观察54种临床常用抗菌药物在转化糖输液中的配伍稳定性。方法测量54种常用抗菌药物在室温下与转化糖注射液配伍后8 h内不同时间的溶液外观性状及pH值变化。结果除外亚胺培南/西司他丁外,其余53种临床常用抗菌药物产品与转化糖输液配伍后外观无明显变化,溶液pH值变化范围≤0.3。结论除外亚胺培南/西司他丁外,其余53种临床常用抗菌药物在常温下与转化糖输液配伍稳定,宜于8 h内使用。

OBJECTIVE To study the compatible stablity between 54 antibiotics for injection and invert sugar infusion. METHODS The appearance of the solution mixed with 54 antibiotics for injection and invert sugar infusion were observed, and the PH assay of the solution were determined. RESULTS Except imipenem and cilastatin sodium,no marked changes were noted in appearance of the other 53 antibiotics production mixed with invert sugar infusion,and the changing ranges≤0.3 in PH assay. CONCLUSION Except imipenem and cilastatin sodium, the other 53 antibiotics can be used within 8h after mixing with invert sugar infusion at room temperature.