血尿酸与急性脑梗死相关性研究——360例急性脑梗死患者相关因素分析

Relationship between blood uric acid and acute cerebral infarction

目的研究血尿酸与急性脑梗死的相关性。方法前瞻性地观察360例急性脑梗死患者与300例非梗死患者血尿酸水平及高尿酸血症(HUA)的发病率。根据血尿酸水平将梗死组患者,分为高尿酸血症组和血尿酸正常组,比较两组患者年龄、性别、体质量、血糖、血脂、血压等指标的差异。比较高尿酸血症组和血尿酸正常组急性脑梗死发病时及治疗后的神经功能缺失程度。结果 (1)梗死组患者的平均血尿酸水平、HUA发病率高于非梗死组。(2)高尿酸组患者的体质量、空腹血糖、血脂水平均高于血尿酸正常组。(3)急性脑梗死发病时高尿酸血症组患者神经功能缺失程度重,经治疗后恢复程度差于血尿酸正常组。结论高尿酸血症与急性脑梗死具有相关性。

ObjectiveTo study the relationship between blood uric acid and acute cerebral infarction.MethodsThe level of blood uric acid and prevalence of hyperuricemia（HUA） were compared in 360 patients with acute cerebral infarction and 300 patients without it.According to the level of blood uric acid,360 acute cerebral infarction patients were divided into HUA and normouricemia（NUA） groups.Age,sex,body mass index（BMI）,blood glucose and total cholesterol were compared between the HUA and NUA group.The degree of neurological functional defection was compared between the two groups when patients were attacked by acute cerebral infarction.After a recovery treatment,the neurological functional defection of the two groups was compared a second time.Results（1）The average blood uric acid level and prevalence of HUA were higher in patients with acute cerebral infarction.（2）The BMI,blood glucose and total cholesterol were higher in HUA group than in NUA group.（3）The neurological functional defection was more serious in HUA group when patients were attacked by acute cerebral infarction and after a recovery treatment.ConclusionHyperuricemia is related to acute cerebral infarction.