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兰索拉唑药动学和药物相互作用的研究进展 被引量:13

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摘要 兰索拉唑为苯并咪唑类衍生物,主要通过抑制H+-K+-ATP酶而发挥抗酸作用,在体内主要经细胞色素P450(CYP)2C19和CYP3A4代谢,酶在不同人群中的差异造成了其体内代谢的个体差异。同时,兰索拉唑有两个立体异构体,两者在体内的代谢也有差异。兰索拉唑经酶代谢会导致与其他经同样酶代谢的药物发生相互作用。该文综述了兰索拉唑的药动学和与其他药物相互作用,及其联合用药的研究进展。
出处 《医药导报》 CAS 2011年第7期922-925,共4页 Herald of Medicine
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参考文献30

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