4-(4-甲氧基苄基氧基)苯丙二酸-4-甲氧基苄基单酯的工艺改进

Improved progress of 4-(4-methoxybenzyloxy)-phenylmalonic acid-4-methoxybenzyl mono-ester

目的 4-(4-甲氧基苄基氧基)苯丙二酸-4-甲氧基苄基单酯的合成工艺改进。方法以对甲氧基苄醇与盐酸反应后生成的对甲氧基苄氯和对羟基苯乙酸为原料,经过酯化和醚化反应及羧基的α位发生羧基化反应得到4-(4-甲氧基苄基氧基)苯丙二酸-4-甲氧基苄基单酯。结果目标产物的结构经过熔点,1H-NMR确认。结论与原工艺相比,改进后的工艺减少了碘化钠的用量,提高了溶剂利用率,收率高,成本低,操作简单。

Objective To improve the process of 4-（4-methoxybenzyloxy）-phenylmalonic acid-4- methoxybenzyl mono-ester. Methods 4-（4-methoxybenzyloxy）-phenylmalonic acid-4-methoxybenzyl mono-ester was synthesized from the main material 4-methoxybenzyl chloride and 4-hydroxyphenylacetic acid by esterification, etherification and carboxylation. Results The structure of final product was confirmed by ^1H-NMR. Conclusion compared with original process, the improved process reduces the amount of sodium iodide and improves the utilization of solvent with high yield, low cost and easy operation.