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嚼食槟榔者口腔鳞癌组织中MT-1、HO-1的表达及意义

Expression of MT-1 and HO-1 in Oral Squamous Cell Carcinoma Caused by Chewing Areca andIts Significance
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摘要 【目的】探讨嚼食槟榔者I：2腔鳞癌组织中MT-1、HO-1的表达及其与临床分期的相关性。【方法】选择18例口腔鳞状细胞癌和18例患者癌旁正常组织标本，采用RTPCR、免疫组化来检测MT-1、HO-1的表达，并分析其与临床分期的相关性。【结果】口腔鳞状细胞癌MT1、HO-1表达显著高于癌旁正常组织（P〈0．05）；MT-1的表达与口腔鳞状细胞癌的N分期和分化程度呈正相关（P〈0．05），与T分期无相关性；HO-1的表达和口腔鳞状细胞癌的N分期呈正相关（P〈0．05），与T分期和分化程度无相关性。【结论】MT-1、HO-l在口腔鳞状细胞癌中高表达，并且和肿瘤的N分期有相关性，对口腔鳞状细胞癌区域淋巴结转移有一定的参考意义。 [Objective]To explore the expression of MT-1 and HO-1 in oral squamous cell carcinoma（OS CC） caused by chewing areca and its relation with clinical stage. [Methods]The specimens of 18 patients with OSCC and adjacent normal tissue of 18 patients were chosen. The expression of MT 1 and HO-1 was detected by reverse transcription polymerase chain reaction（RT-PCR） and immunohistochemistry. Its relation with clinical stage was analyzed. [Results]The expression of MT-1 and HO-1 in OSCC was significant higher than that in adjacent normal tissue（ P〈0.05）. The expression of MT-1 had positive correlation with the N stage and differentiation degree of OSCC（ P〈0.05）, but no correlation with T stage. The expression of HO-1 had pos- itive correlation with N stage of OSCC（P〈0.05）, but no correlation with T stage and differentiation degree. [Conclusion] The expression of MT-1 and HO-1 in OSCC is high and related with N stage of the tumor. Therefore, it had the reference significance for predicting of regional lymph node metastasis in OSCC.
作者 马壮
机构地区 湖南省株洲市一医院口腔科
出处 《医学临床研究》 CAS 2011年第6期1108-1111,共4页 Journal of Clinical Research
关键词 癌 鳞状细胞/病理学 口腔肿瘤/病理学 槟榔属 carcinoma,squamous cell/PAl mouth neoplasms/PA areca
分类号 R739.8 [医药卫生—肿瘤]
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参考文献16

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医学临床研究
2011年 第6期

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