摘要
目的探讨甲状腺乳头状腺癌中血管内皮生长因子-C（VEGF-C）、CD34表达及其临床意义。方法6l例原发性甲状腺肿瘤（乳头状腺癌38例，腺瘤23例）分别应用免疫组化方法检测VEGF-C及CD34表达情况。结果VEGF-C及CD34在各甲状腺肿瘤及间质组织均存在表达，腺癌组VEGF．C（38．24±19．58）显著高于腺瘤组（16．49±9．25）（t=4．9889，P〈0．01），腺癌组CD34表达量[（23．68±9．07）个／HP]高于腺瘤组[（18．704±6．34）个／HP]（t=2．3102，P〈0．05）；VEGF-C在肿瘤有转移（46．35±17．68）、瘤体〉3cm（44．25±20．67）患者中表达高于肿瘤无转移（27。14±10．57）及瘤体≤3cm组（30．81±13．43）（t值分别为4．2082及2．4252，P〈0．05或P〈0．01）；CD34在肿瘤有转移[（29．63±12．52）个／HP]、瘤体〉3cm[（28．35±11．23）个／HP]及年龄〉40岁[（26．24±9．83）个／HP]患者中含量高于无转移[（18．22±5．87）个／HP]、瘤体≤3cm[（19．46±7．55）个／HP]及年龄≤40岁组[（20．354-6．67）个／HP]（t值分别为3．2t03、2．9060及2．1364，P〈0．0l或P〈0．05）；VEGF—C与CD34呈显著正相关（r=0．46，P〈0．01）。结论VEGF—C及CD34的表达与甲状腺肿瘤显著相关，检测VEGF—C及CD34水平对于鉴别甲状腺乳头状腺癌具有重要参考意义。
Objective To study the relationship between VEGF-C, CD34 expression and thyroid papillary tumor tissue by combining assays of VEGF-C and CD34 in thyroid tumor tissue. Methods The expression of VEGF-C and CD34 were dectected by immunohistoehemistry in 61 cases （ thyroid papillary cancer 38,thyroid adenoma 23）. Results VEGF-C level in thyroid papillary cancer （38. 24 ± 19. 58） were significantly higher than that in thyroid adenoma （ 16.49 ±9.25 ,P 〈 0.01 ） ; CD34 in thyroid papillary cancer （ 23.68 ±9. 07 ）/HP were higher than that in thyroid adenoma （ 18.70 ± 6.34, t = 4. 9889, P 〈 0.01 ）. We found a significant relationship between the VEGF-C expression and eancerometastasis or tumor size （P 〈 0.01;P 〈 0. 05 ）. There was also a relationship between the CD34 expression and cancerometastasis or tumor size or age （P 〈0.01 or P 〈 0.05）. There was positive relationship between the expression of VEGF-C and CD34 （r = 0.46 ,P 〈 O. 01 ）. Conclusion It is suggested that combined detections of VEGF-C and CD34 may have important reference value on the differential diagnosis between thyroid papillary tumor tissue.
出处
《中国综合临床》
2011年第7期694-696,共3页
Clinical Medicine of China
基金
广西壮族自治区科技厅自然科学基金资助项目（桂科字0339080）
广西壮族自治区卫生厅重点课题资助项目（重200991）
