不同年龄段的正常糖耐量人群血糖值及其相关因素分析

An analysis on glucose levels and associated factors in normal glucose tolerance subjects of different age

目的分析不同年龄段正常糖耐量（NGT）者血糖水平及相互关系。方法选择上海市杨浦区部分街道流行病学调研2098例30岁以上居民，根据糖耐量（OGTF）检测中空腹血糖值（FPG）和2h血糖值（2hPG），诊断为NGT、糖耐量低减（IGT）、空腹血糖受损（IFG）、IGT合并IFG（IGT／IFG）、糖尿病（DM），将NGT者按年龄分成5组，观察各年龄组的血糖水平，用稳态模式分析胰岛B细胞功能指数（HBCI），并对其进行统计学分析。结果在NGT中60～69年龄组FPG值（5．17±O．48）mmol／L、糖化血红蛋白（HbA1c）（6．01±0．62）％较50一59年龄组FPG值（5．09±0．44）mmol／L、HbA．c值（5．95±0．66）％高（t值分别为2．06、2．48，P均〈0．05）。60～69年龄组FPG值较40～49年龄组FPG值（5．01±0．47）mmol／L高（t=2．26，P〈0．01），50—59年龄组FPG值较40—49年龄组高（t=2．48，P〈0．01），5组按年龄从小至大比较，空腹胰岛素（FINS）值变化无明显规律；60岁以上HBCI较60岁以下的HBCI值下降，差异有统计学意义（F值为33．75，P〈0．01）。结论NGT人群随着年龄的增长，FPG、HbAlc可能增高。

Objective To compare the glucose levels and associated factors among the normal glucose tolerance subjects with different age. Methods Totally a community-based population of 2098 residences aged above 30 years were tested with OGTV, and classified into normal glucose tolerance group （NGT）, impaired glucose tolerance group （IGT）, impaired fasting glucose group （IFG）, both IGT and IFG group （IGT/IFG）, and diabetes group （DM） according to fasting and 2 hours glucose level （2 hPG）. The subjects in NGT group were further divided into 5 groups according to different ages. The levels of blood glucose and HBCI in different groups and subgroups were measured and analyzed statistically. Results For patients in NGT, the FPG （ [ 5.17± 0.48 ] mmol/L vs. [ 5.09 ± 0.44 ] mmol/L, P 〈 0. 05 ） and HbAlc （ [ 6. 01± 0. 62 ] % vs. [ 5.95± 0. 66 ] %, P 〈 0. 05 ） in group aged 60 - 69 were higher than that in group aged 50 - 59. The FPG in group aged 60 - 69 was also higher than those in group aged 40 - 49 （ [ 5.17 ±0. 48 ] mmol/L vs. [ 5.00 ± 0. 47 ] mmol/L, P 〈 0. 01 ） ,and the FPG in group aged 50 - 59 was also higher than those in group aged 40 - 49 （ [ 5.09 ± O. 44 ] mmol/L vs. [5.00 ±0. 47 ] mmol/L, P 〈 0. 01 ）. There was no correlation between age and FINS, while a tendency of decreasing HBCI could be observed along with increasing of age （ F = 33.75, P 〈 0.05 ）. Conclusion In NGT subjects,the FPG and HbA~ C increased along with age.