稳心颗粒与胺碘酮联合转复心房颤动及预防复发的疗效观察

The treatment effect and relapse prevention of cardioversion of atrial fibrillation with Wenxin granulesand amiodarone

目的观察稳心颗粒联合胺碘酮转复及预防心房颤动复发的疗效。方法选择慢性心房颤动患者共60例，随机分为稳心颗粒联合胺碘酮组（A组）及单纯胺碘酮组（B组）各30例，所有患者入院后静脉应用胺碘酮24h同时13服胺碘酮由600m（a逐渐减量至200mg/d维持，另外A组同时给予口服步长稳心颗粒（9g，3次／d）共4周。观察2组患者4周内转复窦性心律情况及半年内复发情况。结果第2、3、4周内累积转复窦性心律例数A组显著高于B组（分别是73．3％与43．3％，X^2=5．55；83．3％与63．3％，X^2=3．07；90．O％与66．7％，X^2=4．81；P均〈0．05），半年内复发B组有高于A组的趋势。结论稳心颗粒联合应用胺碘酮转复心房颤动疗效优于单纯应用胺碘酮，并且半年内复发率可能更低。

Objective To observe the treatment effect and relapse prevention of cardioversion of atrial fibrillation with Wenxin granules and amiodarone. Methods Sixty patients of Chronic atrial fibrillation were divided randomly into treatment of Wenxin granules and amiodarone group （ group A） and treatment of simple amiodarone gorup（ group B） ,Thirty cases in each group. All cases were treated with amiodarone by intravenous drip along with oral amiodarone. Thirty cases in group A were treated with Wenxin granules （9 grams,per day） additionally for 4 weeks. Results＂ Patients in group A resumed normal sinus rhythm significantly higher than that in group B. The increasing relapse tendency of atrial fibrillation was higher in group B within 6 months. Conclusion Drug combination with Wenxin granules and amiodarone has better effect than simple amiodarone in the relapse prevention of cardioversion of atrial fibrillation.