超声辐射下无溶剂合成C-芳基硝酮类化合物

Solvent-free synthesis of C-aryl nitrones under ultrasound irradiation

无溶剂反应条件下,N-取代的羟胺在超声辐射下与芳香醛反应,高产率地合成了一系列C-芳基硝酮并研究了影响产物收率的因素.最佳反应条件为:反应温度60℃,反应时间30 min,超声辐射功率100 W,辐射频率100MHz.在此条件下,合成了15个C-芳基硝酮化合物.该方法具有反应时间短、产率高和操作简便等优点.

Under ultrasonic irradiation,aryl aldehydes react with N-substituted hydroxylamines in solvent-free condition to give C-aryl nitrones.The main process parameters are optimized to reaction temperature 60 ℃,reaction time 30 min,irradiation power 100 W at 100 MHz.Under these conditions,15 compounds are synthesized in high yields.The main advantage of this method over conventional heating method is shortening the reaction time,elevating reaction yield and easy operation.