桑叶粗多糖对糖尿病大鼠糖代谢及脑组织氧化应激的影响

Effect of mulberry leaf polysaccharide on sugar metabolism and oxidative stress in brain tissue of diabetic rats

为探讨桑叶粗多糖抗大鼠糖尿病的机理,将链脲佐菌素(STZ)诱导的糖尿病大鼠用桑叶粗多糖定时灌胃,46 d取血检测血糖、糖化血清蛋白、胰岛素以及左侧脑组织SOD活性和MDA含量.结果表明:桑叶粗多糖对糖尿病大鼠血糖、糖化血清蛋白、胰岛素和脑组织SOD、MDA均有显著性影响.提示桑叶粗多糖通过提高抗氧化能力,促进胰岛素分泌,进而改善糖尿病糖代谢状况.

In order to explore the mechanism of mulberry leaf polysaccharide（MLP）on sugar metabolism and oxidative stress in brain tissue of diabetes rats induced by STZ,the experimental group rats are poured MLP into the stomach every day,the control rats are poured the same quantity water into stomach,the forty-sixth day,all rats are put to death by cutting their heads,then the absorbed blood are used to measured blood glucose,glycosylated serum proteins（GSP）and insulin（Ins）,and the brain tissues of all rats are come off.The SOD activity and MDA content are measured in left brain tissues.The results are as follow：there are significant difference in blood glucose,GSP,Ins,SOD activity and MDA content of left brain tissues between the experimental group and control group.Above results suggest that MLP can promote insulin secretion,and improve the sugar metabolism condition in diabetes rats through increasing the oxidation resistant ability.