过敏性紫癜临床特征及肾脏损害危险因素Logistic回归分析

Clinical Features of Henoch-Schonlein Purpura and Logistic Regression Analysis of Risk Factors of Kidney Damage

目的了解近年来过敏性紫癜住院病例的临床特征,并分析其肾脏损害的危险因素。方法对住院确诊为过敏性紫癜的1941例患儿临床特征进行回顾性分析。结果①过敏性紫癜患儿占同期住院患儿的比例明显增加;6岁到9岁过敏性紫癜患儿占绝大多数;10年来男孩过敏性紫癜病例数的比例有所增加,高于女孩,差异有统计学意义(P<0.05);在临床类型上腹型病例数有所下降,而皮肤型病例数明显增加,差异有统计学意义(P<0.01)。②非紫癜性肾炎及紫癜性肾炎组单因素分析提示年龄、皮疹反复、消化道症状、IgG、PLT、UREA有统计学意义(P<0.05),年龄、皮疹反复、消化道症状在肾脏易感因素Logistic回归分析中有统计学意义(P<0.05)。结论年龄、皮疹反复、消化道症状是过敏性紫癜肾脏损害的危险因素,对于有上述因素的过敏性紫癜患儿更应加强随访。

Objective To understand the clinical features of children＇s Henoch-Schonlein purpura and to analyze the risk factors for the damage of the kidney.Methods Clinical features of 1941 cases with HSP were analyzed retrospectively.Results ①Prevalence of HSP increased;Children aged 6 to 9 years old were the major patients;The male cases increased in ten years;the number of cases of skin were higher than the epigastric type.②The logistic regression analysis showed that age,recurrent rash,and gastrointestinal symptoms were risk factors in Henoch-Schonlein purpura nephritis（P0.05）.Conclusion Age,recurrent rash and gastrointestinal symptoms are the risk factors in Henoch-Schonlein purpura nephritis.