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宁夏汉族Graves病与CYP27B1基因启动子-1260C/A多态性相关性研究 被引量：2

Association between CYP27B1 Gene Promoter Polymorphisms and Patients with Graves' disease in Ningxia Han People
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摘要 目的探讨CYP27B1(Cytochromo P450 CYP)基因启动子C-1260A位点多态性与宁夏汉族Graves病(GD)的相关性。方法采用聚合酶链反应-限制性片段长度多态性(polymerase chain reaction restriction frag-ment length polymorphism,PCR-RFLP)技术,分析汉族GD 99例和正常对照83例CYP27B1基因启动子-1260C/A多态性。结果宁夏汉族CYP27B1基因-1260C/A检出GD组与对照组的基因型频率分别为37.37%、53.54%、9.09%和43.37%、40.96%、15.66%,两组差异无统计学意义(χ2=4.19,P>0.05);等位基因频率为64.16%、35.86%和63.86%、43.14%,两组差异无统计学意义(χ2=0.00,P>0.05)。结论 CYP27B1基因1260C/A的与宁夏地区汉族GD无相关性。 Objective To investigate the association between CYP27B1 gene promoter polymorphisms and patients with Graves＇ disease in Ningxia Han People.Methods A case control study was performed for CYP27B1（1260 C/A） in the promoter region in 99 patients with GD and 83 healthy individuals.The CYP27B1 genotype all cases and control were examined of by polymerase chain reaction restriction fragment length polymorphism（PCR-RFLP）.Results In the promoter（1260） of CYP27B1 gene,the frequencies of genotypes and C/A allele showed no significant difference between cases and controls（P0.05）.Conclusion The position 1260 C/A in the promoter of CYP27B1 may be not susceptible to GD in Ningxia Han people.
作者 康毓芝 陈耀平 杨宝珍 王立斌 吴若芬 师志云 尹琳琳
机构地区 宁夏医科大学 宁夏医科大学总医院医学实验中心
出处 《宁夏医科大学学报》 2011年第6期540-542,共3页 Journal of Ningxia Medical University
基金 宁夏回族自治区研究生教育创新计划项目(D09004)
关键词 GRAVES病 CYP27B1基因 基因多态性 Graves＇ disease CYP27B1gene gene polymorphismd
分类号 R581 [医药卫生—内分泌]
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参考文献14

  • 1Simmonds MJ, Howson JM, Heward JM, et al. A novel and major association of HLA - C in Graves'disease that eclipses the classical HLA- DRBI effect[J]. Hum Mol Genet,2007,16(18) :2149 -2153.
  • 2Chen PL, Fann CS, Chang CC, et al. Linkage of Graves" disease to the humanleucocyte antigen region in the Chi- nese- Han population in Taiwan [ J ]. Clin Endocrinol (Oxf) ,2007,66 (5) :646 - 651.
  • 3Chen PL, Fann CS, Chang CC, et al. Family -based as- sociation study of cytotoxic T - lymphocyte antigen - 4 with susceptibility to Graves'disease in Han population of Taiwan [ J ]. Genes Immun,2008,9 (2) : 87 - 92.
  • 4康毓芝,杨宝珍,王立斌,吴若芬,师志云.宁夏地区Graves′病与CTLA-4基因多态性相关性研究[J].检验医学,2010,25(4):292-295. 被引量：5
  • 5Banmgart| I-IJ, Standl E, Schmidt GH, et al. Changes of vitamin D3serum concentrations at the onset of immune - mediated typel ( insulin - dependent) diabetes mellitus [ J]. Diabetes Res, 1999,16 : 145 - 148.
  • 6Ban Y, Ban Y, Taniyama M, et al. Vitamin D initiation codon polymorphism in Japanese patients with Graves' Disease [ J]. Thyroid,2000,10:375 - 380.
  • 7Lopez ER, Zwermann O, Segni M, et al. A promoter poly- morphism of the CYP27B1 gene is associated with Addi-son' s disease, Hashimoto' s thyroiditis, Graves' disease and type 1 diabetes mellitus in Germans [ J ]. European Journal of Endocrinology,2004,151 : 193 - 197.
  • 8Klaus Badenhoop. CYP27B1 gene polymorphism is associated with Graves' disease in a Polish population study [ J ]. Thyroid ,2005,15 : 1107 - 1108.
  • 9JenningsCE, Owen CJ, Wilson V, et al. Ahaplotype ofthe CYP27B1 promoter is associated with autoimmune Addi- son~ disease but not with Graves'disease in a UK population[ J]. J Mol Endocrinol,2005,34:859 - 863.
  • 10王贤才.希氏内科学[M].21版.西安:世界图书出版西安公司,2003:105-106.

二级参考文献21

  • 1王巧宏,任跃忠.中国人CTLA-4基因外显子1多态性与Graves病的相关性[J].中华内分泌代谢杂志,2003,19(4):297-299. 被引量：11
  • 2Yanagawa T, Hidaka Y, Guimaraes V, et al. CTLA-4 gene polymorphism associated with Graves'disease in a Caucasian population [J]. J Clin Endocrinol Metab, 1995,80( 1 ) :41-45.
  • 3Braun J, Donner H,Siegmund T,et al. CTLA-4 promoter variants in patients with Graves' disease and Hashimoto's thyroiditis [ J ]. Tissue Antigens, 1998, 51 (5) :563-566.
  • 4Park YJ, Chung HK, Park DJ, et al. Polymorphism in the promoter and exon 1 of the cytotoxic T lymphocyte antigen-4 gene associated with autoimmune thyroid disease in Koreans [ J ]. Thyroid, 2000,10 (6) : 453- 459.
  • 5Heward JM, Allahabadia A, Carr-Smith J, etal. No evidence for allelic association of a human CTLA-4 promoter polymorpbism with autoimmune thyroid disease in either population-based case-control or family-based studies [ J J. Clin Endocrinol ( Oxf), 1998,49 (3) :331-334.
  • 6Heward JM, Allahabadia A, Annitage M, et al. The development of Graves'disease and the CTLA-4 gene on chromosome 2q33 [ J ]. J Clin Endoerinol Metab, 1999,84 (7) : 2398-2401.
  • 7Antonio P, Gabriele G, Andrea G, et al. CT 60 single nucleotide polymorphisms of the cytotoxic T- lymphocyte associated antigen-4 gene region is associated with Graves' Disease in an Italian population [ J]. Thyroid, 2005,15 ( 3 ) : 232-238.
  • 8Maurer M,Loserth S,Kolb-Maurer A, et al. A poly- morphism in the human cytotoxic T-lymphocyte antigen 4 ( CTLA4 ) gene ( exon 1 + 49 ) ahers T-cell activation [ J ]. Immunogenetics ,2002,54 (4) : 1-8.
  • 9Simon SM,Blobel G. A protein-conducting channel in the endoplasmic reticulum [ J ]. Cell, 1991,65 ( 3 ) : 371-380.
  • 10Deluca HF, Cantoma MT. Vitamin D: its role and uses in immunology [J]. FASEB, 2001, 15: 2579-85.

共引文献9

同被引文献15

  • 1康东红,邱明才,高硕,李梅,高志红,苏文凌.天津地区汉族人维生素D受体基因多态性与Graves病的关联性研究[J].中华内分泌代谢杂志,2005,21(2):128-129. 被引量：4
  • 2Cantorna MT. Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease[J]. Prog Biophys Mol Biol, 2006,92 (1): 60-64.
  • 3Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response[J]. Science, 2006,311 (5768) : 1770-1773.
  • 4Laverny G,Penna G,Vetrano S,et al. Efficacy of a potent and safe vitamin D receptor agonist for the treatment of inflammatory bowel disease[J]. Immunol Lett, 2010,131 ( 1 ) :49-58.
  • 5Bruce D, Yu S, Ooi JH, et al. Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling [J]. Int Immunol,2011,23(8):519-528.
  • 6Tang J, Zhou R, Luger D, et al. Calcitrioi suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response[J]. J Immunol, 2009,182 (8):4624-4632.
  • 7Adorini L, Penna G. Dendritic cell tolerogenieity: a key mechanism in immunomodulation by vitamin D receptor agonists[J]. Hum Immunol, 2009,70 ( 5 ) : 345-352.
  • 8Yu S, Cantorna MT. The vitamin D receptor is. required for iNKT cell development[J]. Proe Natl Acad Sci U S A, 2008, 105(13) :5207-5212.
  • 9Yu S, Bruce D, Froicu M, et al. Failure of T cell homing, reduced CD4/CD8aa intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice[J]. Proc Natl Acad Sci U S A,2008,105(52):20834-20839.
  • 10Fichna M, Zurawek M, Januszkiewicz-Lewandowska D, et al. Association of the CYP27B1 C(-1260)A polymorphism with autoimmune Addison's disease [J]. Exp Clin Endoerinol Diabetes, 2010,118(8) :544-549.

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二级引证文献4

宁夏医科大学学报
2011年 第6期

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