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3种单环β内酰胺抗生素活性的理论研究 被引量：1

Theoretic Study on Activity of Monocycle βlactams
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摘要 用ＡＭ１ 和ＰＭ３ 方法优化了３ 种单环β内酰胺抗生素的结构，找出结构和活性之间的关系，即活性在结构上的表征．同时对抗生素的药性机理进行了反应动力学研究． In this paper, three β lactams’ geometric configurations have been optimized by AM1 and PM3 methods, the relationship of structure with activity has been found. And the medicinal mechanism have also been studied by reaction kinetics.
作者 毛双 李来才 廖显威
机构地区 四川师范大学化学系
出处 《四川师范大学学报（自然科学版）》 CAS CSCD 1999年第6期713-716,共4页 Journal of Sichuan Normal University（Natural Science）
基金 省教委青年基金
关键词 单环β-内酰胺 抗生素 反应动力学 活性 Monocycle β lactam Reaction mechanism Activity
分类号 TQ465.91 [化学工程—制药化工] R978.1 [医药卫生—药品]
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  • 1黎勇.抗生素的免疫调节作用研究进展[J].内江师范学院学报,2005,20(4):77-80. 被引量：5
  • 2Suntory Ltd. Sun-5555 [J]. Drugs Future,1993,18(16) :525-528.
  • 3Isao kawaoto,Rokuro endo and Shinichi,et al.. Synthesis and antimicrobial activity of a new penems, sodium(5R, 6S)-2-(2- fluoroethylthio) -6-[(1R)-1-hydroxythyl]penems-3- carboxylate [J]. J antibiotics,1986,39(11) ,1551-1556.
  • 4Neu H C and,Labthavikul P. Antibacteral activity of an oral penem, Sch29482 [J]. J. Antimicrob. chemother. 1982,9 (Suppl. C) :49-57.
  • 5Nishi T, Higashi K, Soga T,et al. Synthesis and antibac-terial activity of new2-substituted penems Ⅱ [J]. J Antibiot(Tokyo), 1994, 47(3) :357-369.
  • 6Emmer G, Kneussel P, Hildebrandt J. Synthesis and bio-logical activities of new penem derivatives with side chains derived from 4-hydroxyproline [J]. J Antibiot (Tokyo), 1985, 38(10) : 1371-1386.
  • 7Sunagawa M, Matsumura H, Inoue T,et al. New penem compoumds with 5'-substituted pyrrolidinylthio group as a C-2 side chain; comparison of their biological properties with those of carbapenem compounds [J]. J Antibiot(Tokyo), 1992, 45(4) : 500-504.
  • 8Viyyoor M,Girijavallabhan,Ashit K. Ganguly,et al. A new class of penems C-2-N-substituted compounds-synthesis and antibacterial activity [J]. J antibiotics, 39(8), 1187-1190.
  • 9Neu H C,Hin N and Labthavikul P. The in-vitro activity of a novel penem FCE22101 compared to other β-lactam antibiotics[J]. J. Atimicrob. chemother. 198516:305-313.
  • 10Matsuda,Sasaki K K, Inoue K, Kondo H, In vitro antibacterial activity of Sch34343 and its stability toβ-lactamase and renal dehydropeptidase 1 [J]. Antimicrob. Agents Chemother. 1985.28:684-688 .

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四川师范大学学报（自然科学版）
1999年 第6期

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