PICU中侵袭性真菌感染防治策略

Prevention Strategy of Invasive Fungal Infection in PICU

目的通过对PICU侵袭性真菌感染(IFI)病例的感染位置、真菌种类数量、临床危险因素的研究针对性的提出防治策略。方法 52例患儿均取感染组织的病理样本进行微生物学检验,记录各患者感染情况、部位、主要菌群、群丝数量,以及临床可能存在的诱发IFI的高危因素等。结果白色念珠菌是IFI最主要的感染真菌(60.87%),经组内比较明显高于其他菌种(t=11.32,P<0.05);呼吸系统(44.57%)、消化系统(23.91%)和泌尿系统(16.30%)是最主要的感染部位,经组内比较明显高于其他菌种(t=8.27、5.44、3.62,P<0.05);插管92.31%、侵袭性操作84.62%、广谱抗生素联合使用两种以上76.92%是引发IFI的高危因素。结论 PICU中的IFI发病应早预防早治疗,以提高临床的防治效果。

Objective To focus on a prevention strategy based on the IFI study of infection location,number of fungal species and risk factors in PICU.Methods The pathological smples of infected tissue from 52 IFI children were checked by microbiology.Recording the infection condition,location,main flora,fungi number,and risk factors of every children.Results Candida albicans was the main infecting fungi of IFI（t=11.32,P0.05）.Respiratory system（44.57%）,digestive system（23.91%） and urinary tract（16.30%） were the main infection location with IFI children（t=8.27,5.44,3.62,P0.05）.Intubation 92.31%,invasive operation 84.62% and joint use more than 2 kinds of broad-spectrum antibiotics 76.92% were the risk factors of IFI.Conclusion IFI in PICU should be early prevention and early treatment in order to improve the clinical effects.