频发腹膜透析相关性腹膜炎患者血清及透出液C反应蛋白和CA125检测的意义

The Significance of Serum and Dialysate CRP and CA125 Levels in the Frequency Peritoneal Dialysis-related Peritonitis Patients

目的:探讨频发腹膜透析相关性腹膜炎患者血清及透出液C反应蛋白(CRP)和癌抗原125(CA125)浓度变化的临床意义。方法:采用放射免疫法及自动生化仪检测腹膜透析相关性腹膜炎患者抗感染治疗前后血清及透出液CRP和CA125浓度。1年内发生2次及以上腹膜炎的患者归入频发腹膜炎组(A组)共15例,其余44例归入单纯腹膜炎组(B组),对照分析两组间数据。结果:治疗后血清及透出液CRP水平A组>B组(P<0.05)。在腹膜炎感染期,两组透出液CA125均升高,差异无统计学意义(P>0.05);腹膜炎治疗后透出液CA125均降低,A组首次腹膜炎治疗后透出液CA125水平与B组相当(P>0.05),A组末次腹膜炎治疗后透出液CA125水平较B组低(P<0.05)。结论:检测CAPD并发感染性腹膜炎患者血清及透出液CRP和CA125浓度的变化,对评估腹膜炎的预后及评价腹膜功能具有指导意义。

Objective：To identify the clinical significance of the changes of serum and dialysate C-reactive protein（CRP） and CA125 levels in the frequency peritoneal dialysis-related peritonitis.Method：Serum and dialysate CRP and CA125 levels of peritoneal dialysis-related peritonitis patients were detected in emission immunization and using the automatic biochemistry meter before or after anti-infection treatment.15 patients with two or more onsets in one year were induced into group A,the frequency peritoneal dialysis-related peritonitis group,and the other 44 patients were induced into group B,the pure peritonitis group,served as the control group.The clinical and laboratory data of the two groups were compared and analyzed.Result：Compared with those in the control group,after anti-infection treatment the patients in group A had significantly higher serum and dialysate CRP levels（P〈0.05） than that in group B,but the similarly reduced dialysate CA125 levels.During the infection,dialysate CA125 levels in two groups were both increased,but non-statistics significance（P〉0.05）.And at the the first time of anti-infection treatment,dialysate CA125 levels in group A were the same as group B（P〉0.05）,but at the the last time were lower than that in group B（P〈0.05）.Conclusion：Detecting the change of serum and dialysate CRP and CA125 levels in the frequency peritoneal dialysis-related peritonitis patients is instructive to estimate the prognosis of peritonitis and the function of peritoneum.