小剂量米非司酮在子宫腺肌病治疗中的临床疗效分析

Small Dose of Mifepristone in the Treatment of Adenomyosis the Efficacy Analysis

目的:探讨小剂量米非司酮在子宫腺肌病治疗中的临床疗效。方法:回顾性分析我院收治的87例确诊为子宫腺肌病的患者资料,给予患者米非司酮10mg/d,连用6个月,疗程结束后对所有患者停药后随访6个月,观察用药前后患者疼痛程度、月经周期、经期、子宫体积等指标变化情况。结果:疗程结束后,所有患者痛经程度用药后较用药前明显减低,月经异常明显改善;减少了病情对患者活动程度的影响,明显改善并提高了患者的活动能力;缩小了患者的子宫体积,治疗前后患者的疼痛程度、痛经分级、月经周期、经期及经量、子宫体积上的比较差异显著(P<0.05或P<0.01),有统计学意义。结论:小剂量米非司酮治疗子宫腺肌病疗效显著,副作用小。

Objective：To investigate the dose of mifepristone in the treatment of adenomyosis results.Methods：A retrospective analysis of our hospital from June 2007~June 2010 87 patients were treated adenomyosis diagnosed patients with information,patients mifepristone 10mg/d,used in conjunction 6 months after the end of treatment All were followed up for 6 months after stopping to observe the degree of pain in patients before and after treatment,menstrual cycle,menstruation,uterine volume and other indicators of change.Results：All patients after treatment,after treatment the degree of dysmenorrhea was significantly lower than before treatment,significant improvement in menstrual abnormalities;reduced disease activity level of patients,significant improvement and increase the patient＇s activity;reduced uterine volume of patients,treatment before and after the patient＇s pain,dysmenorrhea grade,menstrual cycle,menstruation,and by the amount of difference on the uterine volume was significantly（P0.05 or P0.01）,was statistically significant.Conclusion：Low dose mifepristone treatment of adenomyosis significant effect,side effects.