54例乳腺癌患者前哨淋巴结亚甲蓝染色法活检临床分析

54 Cases of Breast Cancer Sentinel Lymph Node Biopsy in Clinical Analysis of Methylene Blue Staining

目的:运用前哨淋巴结活检对乳腺癌患者的淋巴结转移情况进行判断。方法:54例均系2006年6月—2008年12月在我院外科接受手术的乳腺癌患者,术中注射亚甲蓝定位前哨淋巴结(SLN)并活检,后行常规腋窝淋巴结清扫,术后进行病理检查。结果:本组54例乳腺癌中,检出SLN49例,检出率为90.74%(49/54)。24例SLN阳性患者中,ALND阳性16例,ALND阴性8例;25例SLN阴性患者中,ALND阳性3例,ALND阴性22例。准确率为93.88%(46/49),灵敏度为88.89%(24/27),假阴性率为11.11%(3/27)。SLN检出率与患者年龄、组织学分型无明显相关(P>0.05),与肿瘤大小、腋窝淋巴结状态显著相关(P<0.05)。结论:亚甲蓝染色法SLNB技术临床可行,前哨淋巴结活检能准确预测乳腺癌腋窝淋巴结状态。

Objective：To evaluate sentinel lymph node biopsy in breast cancer patients with lymph node metastasis to judge.Methods：54 patients were department from June 2006 to December 2008 in oncology breast cancer surgery,intraoperative injection of methylene blue localization of sentinel lymph node（SLN）and biopsy,underwent conventional axillary lymph node dissection postoperative pathological examination.Results：among 54 cases of breast cancer detection SLN 49 cases,the detection rate was 90.74%（49/54）.24 patients with SLN-positive patients,ALND positive in 16 cases,ALND negative in 8 cases;25 patients with SLN-negative patients,ALND positive in 3 cases,ALND negative in 22 cases.Accuracy was 93.88%（46/49）,sensitivity was 88.89%（24/27）,false negative rate was 11.11%（3/27）.SLN detection rate with age,histological type had no significant correlation（P0.05）,and tumor size,axillary lymph node status was significantly associated（P0.05）. Conclusion：The technique of methylene blue staining of clinical feasibility SLNB,sentinel lymph node biopsy can accurately predict the axillary lymph node status.