对位取代苯酚葡萄糖氧甙类化合物红外光谱特征

Infrared Spectroscopy Characteristics of Some p-Substituted Phenyl-β-D-glucosides

在对位取代苯酚葡萄糖甙类化合物结构与活性关系的研究过程中，发现了强烈抑制端粒酶活性的化合物，此类化合物经西德ＰＥ－ １７１０ 型红外光谱仪测得红外光谱吸收表明，其Ｃ－ Ｏ 键、葡萄糖吡喃环及苯环的吸收呈现明显的红外光谱特征，即随化合物电负性的规律性变化，其红外光谱吸收也呈现规律性变化．此外，进一步讨论了Ｃ１ － Ｈ 核磁共振位移与葡萄糖吡喃环红外吸收峰的关系．迄今尚未发现类似的研究报道．

In this paper,some p-substituted phenyl-β-D-glucosides with tolemere enzyme inhibition activity are studied with the aid of Western Germany PE-1710 model IR spectroscopy.The configuration including C-O band,tetrahydropyranoid ring and benzene ring as well as special IR shift features are investgated.It shows that with the regular modification of compounds'electronegativity the IR shifts regularly as well.Furthemore,with 1H-NMR method,some glucopyranosyls are discussed.No similar research reports are seen as yet.