对甲氧基苯乙酮与间(对)硝基苯甲醛、芳香胺的Mannich反应

The Mannich reaction among p-methoxyacetophenone, m-nitrobenzaldehyde or p-nitrbenzadehyde and arylamines

对甲氧基苯乙酮与间硝基苯甲醛或对硝基苯甲醛和芳香胺在０￣３５℃和催化量浓盐酸存在下可直接发生Ｍａｎｎｉｃｈ反应，生成了相应的Ｍａｎｎｉｃｈ碱（１）－１，３－二芳基－３－芳氨基－１－丙酮，共１６个新的化合物，产率为６２．７％￣９２．２％。产物结构经ＩＲ，＾１ＨＮＭＲ，ＭＳ鉴定，并用正交实验法研究了反应适宜条件，讨论了反应物结构与Ｍａｎｎｉｃｈ反应的关系。

Under the catalytic amount of concentrated hydrochoric acid, the Mannich reaction of p-methoxyace-tophenone, m-nitrobenzaldehyde or p-nitrobenzaldehyde and arydrines can be cAned out directly at 0~35℃. Sixteen corrsponing Mannich bases(Ⅰ)──1, 3-diarel-3-(arylamino) propanones were Prepared with 62. 7% ~92.2% yield. All of these Mannich bases(Ⅰ) are new compounds, their structures were confirmed by IR, MS, The reaction conditions were also discussed by orthogonal designing method. The relation betwen the structure of substrate and the forich reaction is discusse.