褪黑素对肾血管性高血压大鼠的肾脏保护作用及其机制研究
摘要
研究表明,在许多高血压肾损害的动物模型中,存在着氧自由基（OFR）的大量生成及其活性增加、抗氧化酶活性的降低,提示氧化应激在高血压肾损害的发生和发展中起重要作用。褪黑素（MLT）是松果体分泌的吲哚类神经内分泌激素,是一种强抗氧化剂．能够显著减轻氧自由基的损伤。已有研究显示MLT可对多种因素导致的肾脏损伤有保护作用，可能与其抗氧化作用有关。本研究采用褪黑素干预治疗2K1C高血压大鼠．研究其对血压的调节及其对肾脏的保护作用。
出处
《中国药物与临床》
CAS
2011年第7期789-791,共3页
Chinese Remedies & Clinics
基金
山西省高校科技研究开发项目(200713058)
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