孟鲁司特对哮喘患者血清炎症细胞因子和肺功能的影响

The Influence of Montelukast to Asthma Patients Serum Inflammatory Cytokines Expression and Lung Function

目的观察孟鲁司特对哮喘患者血清白细胞介素10、白三烯B4水平和肺功能的影响。方法将60例急性发作期支气管哮喘患者随机均分为两组,对照组仅常规吸入激素治疗;治疗组在对照组治疗基础上口服孟鲁司特钠片10 mg/次,每晚1次,连用3月。均于治疗前和治疗3月后抽取静脉血检测白细胞介素10、白三烯B4水平和肺功能变化。结果与治疗前比较,两组治疗后血清白细胞介素10水平均明显上升(P<0.05或P<0.01),治疗组上升更明显(P<0.05);两组治疗后白三烯B4水平明显下降(P<0.05或P<0.01),治疗组下降更明显(P<0.05);两组治疗后肺功能指标明显改善(P<0.05或P<0.01),且治疗组改善更明显(P<0.05)。结论孟鲁司特可上调白细胞介素10水平、降低白三烯B4水平,从而抑制气道炎症、缓解气道痉挛、降低气道高反应性,改善肺功能。

Objective observation the influence of montelukast to asthma patients serum IL-10,LTB-4 level and lung function.Methods 60 patients with acute episode bronchus asthma patients were randomly divided into two groups：the control group（are only the regular use of inhaled hormone therapy.The treatment group give montelukast to oral except the therapy of control group,10 mg/times,1 piece every night,continued to three months,all before treatment and after therapy of three months extraction venous blood testing IL-10,LTB-4 level and measurementing lung function changes.Results compared with before treatment,serum IL-10 levels are increased obviously（P 0.05 or P 0.01）,the treatment group rise more obviously（P 0.05）,LTB-4 levels decreased obviously（P 0.05 or P 0.01）,the treatment group dropped more obviously（P 0.05）.Two groups of patients after treatment significantly improved lung function（P 0.05 or P 0.01）,and the treatment group improve significantly（P 0.05）.Conclusion montelukast can raise IL-10 level,reduce the LTB-4 level,thus inhibiting airway inflammation,relieve airway spasms,lower airway responsieness,improve lung function.