异甘草酸镁治疗药物性肝损害的临床疗效探讨

Exploration of therapeutic effects of Magnesuim Isoglycyrrhizinate on drug-induced liver injury

目的探讨异甘草酸镁治疗药物性肝损害的临床疗效。方法选取24例药物性肝损害住院患者,随机分为治疗组12例和对照组12例,2组均以常规护肝治疗,治疗组在常规护肝基础上加用异甘草酸镁0.1 g+10%葡萄糖注射液250mL,静脉滴注1次/d,疗程1个月。观察2组治疗前后血清丙氨酸转氨酶(ALT)、谷草转氨酶(AST)、血清总胆红素(TBIL)、γ-谷氨酰转肽酶(GGT)和碱性磷酸酶(ALP)的变化情况,以及2组患者住院天数的差异。结果与对照组相比,异甘草酸镁治疗急性药物性肝损害能明显改善肝功能(P均<0.01),住院天数显著缩短(P<0.01)。结论异甘草酸镁治疗急性药物性肝损害的效果较好,值得临床推广使用。

Objective To explore the therapeutic effects of City Magnesium Isoglycyrrhizinate on resistance against drug-induced liver injury.Methods Twenty-four patients in hospital were randomly divided into treatment group（12 cases） and control group（12 cases）.Both groups were given routine protection of liver.Treatment group was added the injection of Magnesium Isoglycyrrhizinate of 1.0 g and glucose of 250 ml once everyday for one month.The changes between pre-treatment and post-treatment in ALT,AST,TBIL,GGT,ALP and inpatient days were observed.Results Compared with control group,the liver function indices of treatment group improved obviously（P0.01）,and the impatient days were shorter as well（P0.01）.Conclusion The Magnesuim Isoglycyrrhizinate has excellent effects on resistance against drug-induced liver injury.It is worthy of further clinical application.