P(LA-PEG-LA)/NIPA共聚水凝胶的合成及其性能

Synthesis and properties of P(LA-PEG-LA)/NIPA copolymer hydrogels

以丙交酯(LA)和聚乙二醇(PEG)为单体,通过微波辅助合成P(LA-PEG-LA)寡聚聚酯,然后与丙烯酰氯反应制备能够自聚形成水凝胶的大分子单体.所制备的寡居聚酯及大分子单体均经FT-IR及1H NMR表征.制备的大分子单体与N-异丙基丙烯酰胺(NIPA)共聚制备一系列水凝胶.在大分子单体投料量较低时,水凝胶表现出PNIPA的低临界溶解温度(LCST)特性,并具有很高的吸水溶胀率.在大分子单体投料量高于NIPA时,在NIPA的LCST以上,这一系列水凝胶不收缩,反而呈现出更大的溶胀率.

Microwave-assisted preparation of polyester oligomer by ring-opening polymerization of lactide（LA） using poly ethylene glycol（PEG） as a co-monomer was studied.The polyester oligomer could further react with acryloyl chloride to produce macromolecule monomer which could undergo self-polymerization.Copolymerization of the macromolecule monomer and N-isopropylacrylamide（NIPA） to prepare hydrogels was then studied.It was found that the hydrogels with low feed ratios of the macromolecule monomer to NIPA would show LCST of PNIPA and excellent swelling properties.The copolymer hydrogels would not shrink above LCST but show higher swelling ratios when the dose of the macromolecule monomer was higher than that of NIPA.