来曲唑用于不孕症促排卵作用的临床研究

Clinical research on the use of Letrozdefor promoting ovulation in female infertiling

目的将不孕症多囊卵巢综合征(PCOS)患者58例分别用来曲唑(LE)与克罗米酚(CC)治疗促排卵,比较两组药物对卵泡发育及子宫内膜的影响。方法选择PCOS 58例随机分成两组服药促排卵,服用来曲唑(LE)30例为治疗组,服用克罗米酚(CC)28例为对照组,观察两组卵泡发育及子宫内膜的影响及妊娠率。结果来曲唑组出现优势卵泡21例(70.0%),克罗米酚组8例(28.6%),两组比较差异有统计学意义(P<0.01);HCG日LE组≥16 mm卵泡数明显少于CC组,子宫内膜厚度较厚;LE组妊娠率高于CC组;CC组出现1例卵巢过度刺激综合征,2例出现卵巢早衰。结论来曲唑促排卵效果好,单卵泡发生率高,降低卵巢过度刺激综合征,妊娠率高。克罗米芬对卵巢过度刺激易引起卵巢早衰。

Objective A total of 58 cases patients with polycystic ovarian syndrome （PCOS） are respectively treated by letrozole （LE） and clomiphene citrate （CC） for promoting ovulation, then comparing the effects of two kinds of drugs on follicle growth and endometrium. Methods A total of 58 cases patients with PCOS were at random divided into two groups： Treatment group of 30 cases, treated by LE ; control group of 28 cases, treated by CC. The follicle growth, effects on endome- trium and pregnancy rate in two groups were observed. Results 21 cases had dominant follicle in the group treated by LE （70.0%） and 8 cases had dominant follicle in the group treated by CC （28%） , in which the differences had statistical sig- nificance （P 〈 0.01 ）. During the HCG period, the follicles that greater than or equal to 16 mm in LE group were obviously less than those in CC group, the thickness of endometrium was bigger and the pregnancy rate was higher respectively than that in CC group. Only 1 case had ovarian hyperstimulation syndrome and 2 case had premature ovarian failure in CC group. Con- clusion Using the LE to promote ovulation is effective with high incidence of single follicle and high rate of pregnancy and al- so could drop the incidence of ovarian byperstimalation syndrome. The hyper stimulation of elomiphene citrate on ovary would easily cause the premature ovarian failure.