海洋胶原肽长期喂养对SD大鼠自发肿瘤的抑制作用

The Inhibitory Effect of Long-term Feeding with Marine Collagen Peptide on the Spontaneous Tumor of Sprague-dawley Rat

为探讨海洋胶原肽(MCP)对自然衰老过程中自发肿瘤的影响,选用4周龄初断乳SD大鼠,雌雄各半,随机分为四个组,分别在空白标准饲料的基础上添加0%、2.25%、4.5%和9%MCP进行终生喂养,并对各组自发肿瘤的发生情况和生存时间进行观察。结果表明,MCP干预组雌雄SD大鼠自发肿瘤率有一定程度的下降,其中雌性9%干预组、雄性4.5%和9%干预组与对照组的差异具有显著性。各组乳腺肿瘤潜伏期及生长时间没有显著的组间差异,而2.25%与4.5%MCP雌性干预组乳腺肿瘤的体积与对照组相比显著减小;雌雄9%MCP干预组荷瘤大鼠的生存时间较对照组有显著延长;MCP干预组大鼠以肿瘤作为主要死因的比例与对照组相比呈明显下降的趋势。结果提示,MCP长期喂养对SD大鼠的自发肿瘤的发生及发展具有一定的抑制作用。

To observe the effect of long-term feeding marine collagen peptide on the incidence and development of the spontaneous tumor, Sprague-Dawley rats at the age of 4-week were divided into the control group and three experimental groups. Control rats were fed with standard rat diet and the MCP-treated rats were fed with 2.25% ,4.5% and 9% （wt/wt） MCP throughout the lifespan. The results showed that the spontaneous tumor incidence of MCP-treated rats were obviously decreased compared with the control rats, with significance in the 9% MCP-treated female group and the 4.5% and 9% MCP-treated male groups; the long-term administration of MCP did not affect the palpable time and growth time of mammary gland tumor and the final volume of mammary gland tumor of the 2.25% and 4. 5% MCP-treated groups were significantly decreased compared with the control group; the lifespan of tumor-bearing rats in the MCP-treated groups were prolonged, with significance in the 9% MCP-treated groups; compared to the control group, the incidence of death from tumors was decreased in MCP-treated groups in comparison with the control group of both sexes. In conclusion, the long-term administration of MCP might have some inhibitory effect on the incidence and the development of spontaneous tumor.