细胞凋亡相关蛋白Bax,Bcl-2在子痫前期患者胎盘滋养细胞中的表达及意义

The expression of Bax and Bcl-2 proteins in placenta and their significance in patients with preeclampsia

目的通过研究轻、重度子痫前期患者和正常妊娠孕妇胎盘滋养细胞Bax,Bcl-2蛋白的表达情况,来分析胎盘滋养细胞Bax,Bcl-2蛋白在子痫前期发病过程中的作用。方法用免疫组化方法(SP法)检验胎盘中Bax,Bcl-2蛋白的表达。结果轻、重度子痫前期患者组胎盘Bax阳性表达强度显著高于对照组,各组间结果差异有统计学意义(P<0.05),随着病情加重表达增加。轻、重度子痫前期患者组胎盘Bcl-2阳性表达强度显著低于对照组,各组间结果差异有统计学意义(P<0.05),随着病情加重表达降低。结论轻、重度子痫前期患者组胎盘Bcl-2阳性表达强度降低,Bax阳性表达增加,它可能参与子痫前期的发病。

Objective： To observe the relationship between the placental expressions of Bax and Bcl-2 proteins and the pathogenesis of preeclampsia.Methods： The expressions of Bcl-2 and Bax proteins were detected by immunohistochemical methods.Results： The positive degree of Bax expression in the placenta of moderate and severe preeclampsia were significantly higher than those in the control groups（P0.05）;there was remarkable difference among the three groups.With the development of the disease,the expressions of Bax were increased.The positive degree of Bcl-2 expression in the placenta of moderate and severe preeclampsia were significantly lower than those in the control group;there was remarkable difference between the three groups.With the development of the disease（P0.05）,the expressions of Bcl-2 were decreaesed.Conclusion：The expressions of Bax increase and expressions of Bcl-2 decrease.The changes of Bax and Bcl-2 expression may play an important role in the pathophysiologic mechanism of preeclampsia.