48例急性药物性肝损害临床特点分析

Clinical Features of 48 Patients with Drug-induced Acute Hepatic Lesions

目的探讨急性药物性肝损害的临床特点。方法回顾性分析我院2008年6月～2010年6月间48例急性药物性肝损害患者的临床特点。结果引起急性药物性肝损害的药物种类较多,第一位是中草药（18/48,37.5%）,其次为抗结核药（8/48,16.7%）、抗生素（6/48,12.5%）等。其中,肝细胞损伤型占52.1%（25/48）,胆汁淤积型占18.8%（9/48）,混合型占29.2%（14/48）。结论引起急性药物性肝损害的药物种类较多,应引起重视。

Objective To analyse the clinical features of drug-induced acute hepatic lesions.Methods The clinical data of 48 drug-induced acute hepatic lesion cases collected from Jun.2008 to Jun.2010 in our hospital were analyzed respectively.Results Most of the therapeutic agents might cause the liver dysfunctions,of which the highest incidence rate was due to the type of Chinese herbal medicines（18/48,37.5%）,and the next was due to anti-tuberculosis agents（8/48,16.7%）,antibiotics（6/48,12.5%）,etal;52.1%（25/48） were hepatocellular damage type,18.8%（9/48） cholestatic damage type and 29.2%（14/48） damage of mixed type damage.Conclusions Hepatic lesions were not specificity in clinical features;various drugs can lead to hepatic lesions and we should pay attention to it clinically.