卡维地洛改善急性心肌梗死后左心室重构的临床研究

The Effect of Carvedilol on Ventricular Remodeling after Acute Myocardial Infarction

目的观察卡维地洛对急性心肌梗死（AMI）后左心室重构的影响。方法将我科收治的100例AMI患者随机分为观察组与对照组,两组均给予常规治疗,观察组在常规治疗基础上加用卡维地洛治疗,两组治疗前后行心超检查,比较两组治疗前后左心室舒张末期内径（LVEDD）、左室收缩末期内径（LVESD）、左心室舒张末期容量（LVEDV）、左心室收缩末期容量（LVESV）和左心室射血分数（LVEF）的变化。结果治疗24周后观察组LVEF值、LVEDD、LVESD、LVESV均较治疗前显著改善（P〈0.05或P〈0.01）,而对照组变化无统计学差异（P〉0.05）。随访24周期间,对照组心力衰竭发生率8.0%（4/50）,观察组为6.0%（4/50）,差异无统计学意义（P〉0.05）。结论卡维地洛具有良好的防止AMI后左心室重构的作用。

Objective To explore the effect of carvedilol on ventricular remodeling after acute myocardial infarction（AMI）.Methods 100 patients of AMI treated in our department were randomly divided into two groups,all patients were given conventional treatment,the observation group were given carvedilol based on the conventional treatment.Both groups before and after treatment were inspected by echocardiography to obtain the end left ventricular diastolic dimension（LVEDD）,end left ventricular systolic dimension（LVESD）,end left ventricular diasto licvolume（LVEDV）,end left ventricular stroke volume（LVESV） and left ventricular ejection fraction（LVEF）.Results After 24 weeks of treatment the LVEF values,LVEDD,LVESD,LVESV in the observation group were significantly improved compared with before treatment（P0.05 or P 0.01）,but changes in the control group were no significant difference（P 0.05）.The incidence of heart failure in the control group was 8.0%（4/ 50）,and that in the observation group was 6.0%（3 / 50）,the difference was no statistically significant（P 0.05）.Conclusions Carvedilol has a good effect on the inhibition of left ventricular remodeling after AMI.