卡介菌多糖核酸治疗慢性荨麻疹的疗效观察

Investigate the Efficacy of BCG-PSN in Chronic Urticaria Patients

目的观察卡介菌多糖核酸联合左西替利嗪治疗慢性荨麻疹的-陆床疗效及安全性。方法将98例慢性荨麻疹患者随机分为2组，治疗组：采用卡介菌多糖核酸注射液肌肉注射0．7毫克，每周2次，连续治疗12周，同时口服左西替利嗪5毫克，每日1次，连续4周。对照组：单独1：7服左西替利嗪5毫克。每日1次，连续4周。结果4周后观察疗效，治疗组有效率为73．5％，对照组为51．0％（P〈0．05），12周后治疗组有效率为75．5％，对照组为34．7％，两组比照差异有显著性（P〈0．01）。结论卡介菌多糖核酸联合左西替利嗪治疗慢性荨麻疹疗效确切。

Objective To investigate the efficacy and safety of BCG-PSN in chronic urticaria patients. Methods 98 urticaria patients were divided randomly into 2 groups, 49 cases took BCG-PSN, 0.7mg muscle injeetion,twiee every week, 12 weeks and levoeetirizine hydroehloride tablets 5mg, once every day, 4 weeks. 49 controls took levocetirizine hydroehloride tablets, 5mg, once every day, 4 weeks. Results After 4 weeks, the effective rate were 73.5% in the observation group, and were 51.0% in the eontrols （P〈0.05）. After 12 weeks, the effective rate were 75.5% in the observation group, and were 34.7% in the control （P〈0.01）. Conclusion BCG-PSN and levocetirizine hydroehloride tablets has obvious effects in the treatment of chronic urticaria