极低出生体重儿持续气道正压通气联合药物雾化的效果研究

The effect of continuous positive airway pressure combined with atomizing inhalation on very low birth weight infants

目的 探讨极低出生体重儿呼吸暂停持续气道正压通气联合药物雾化的效果.方法 将56例同期入院的极低出生体重儿伴发呼吸暂停随机分为两组,观察组28例,施行持续气道正压通气时及2 h后,给予药物雾化;对照组28例,按常规持续气道正压通气.结果 观察组鼻咽部干燥症状、管道堵塞发生数、痰液黏稠度显著低于对照组（P值均〈0.01）,观察组持续气道正压通气时间与对照组相比明显缩短,呼吸暂停发生数、并发症发生率观察组少于对照组（P值均〈0.01）.结论 极低出生体重儿持续气道正压通气联合药物雾化,有效减少呼吸暂停的发生次数,减低并发症发生率,提高存活质量.

Objective To investigate the effect of continuous positive airway pressure combined with atomizing inhalation on very low birth weight infants who were apnea.Methods A total of 56 infant patients with apnea were involved in this study and divided into two groups.Observation group consist of 28 cases and were treated with continuous positive airway pressure and atomizing inhalation 2 hours later;Control group consist of 28 cases and were treated with continuous positive airway pressure.Results The symptoms of nasopharyngeal dry, the number of pipe blocking and the sputum viscosity was significantly in observation group lower than that in control group （P all〈0.01）, the time of observation group＇s continuous positive airway pressure ventilation was significantly shorter than that of control group;Observation group had lower incidence of apnea and complications than control group. （P all〈0.01）.Conclusions The method of continuous positive airway pressure combined with atomizing inhalation may effectively reduce incidence of apnea and complications and improve the life quality.