可溶性MICA在胆管癌患者外周血中表达及其临床意义

Expression of Serum Soluble MICA Protein in Patients with Cholangiocarcinoma and Its Significance

目的:探讨可溶性MICA(sMICA)在胆管癌患者外周血中的表达及其临床意义。方法:应用酶联免疫吸附试验法(ELISA)检测42例胆管癌患者的外周血sMICA的表达水平,分析其与临床病理特征的关系。结果:胆管癌患者血清sMICA水平显著高于正常对照组(P<0.01);胆管癌患者血清中sMICA的表达水平与血清中CA19-9水平、肿瘤浸润及淋巴结转移等临床病理特征密切相关(P<0.05);手术后胆管癌患者血清中sMICA水平明显下降。结论:胆管癌患者血清中sMICA水平明显增高,血清sMICA可作为胆管癌诊断的一种重要的指标。

Objective： To investigate the expression of serum soluble MICA protein in peripheral blood in the patients with cholangiocarcinoma and its clinical significance.Methods： Samples of 42 cholangiocarcinoma patients and 40 healthy persons were col-lected to detect Serum levels of sMICA by MICA-specific enzyme-linked immunosorbent assay.The association of serum sMICA levels wth clinical features were statistically analyzed.Results： The serum levels of sMICA was found to be significantly elevated in the pa-tients with cholangiocarcinoma compared with heathy subjects（P0.01）.The levels of sMICA correlated significantly with CA19-9 level,tumor infltration and lymph node metastasis（all P0.05）.The successful tumor resection significantly decreased serum levels of soluble MICA.Conclusion： Serum MICA levels of patients with cholangiocarcinoma are significantly increased,it is one of the important param-eters for clinical evaluation in patients with cholangiocarcinoma.